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Primary Phone: (520) 6262567
Thomas W. Keating Bioresearch Building, Room 339
Primary Phone: (520) 6262567
MD, University of Florence, Italy, 1978
- College Of Medicine
Her latest research focuses on asthma epigenetics and the mechanisms through which farming environments confer strong protection against asthma in human populations and animal models.
Environmental Health Research & Expertise:
Dr. Vercelli acts as the Co-Director of the Career Development Core, a key educational component designed to foster the research efforts of both junior and senior scientists interested in environmental health, particularly in the context of human complex diseases such as asthma, diabetes and cancer. Her research work is internationally renowned and is at the cutting edge of both immunology and complex disease biology. Her laboratory is generally recognized as one of the leaders in the effort to understand the function of disease-associated genetic variants and gene-environment interactions. Dr. Vercelli is leading the development of multi-disciplinary complex disease research at the University of Arizona by serving as Director of the Arizona Initiative for the Biology of Complex Diseases (ABCD).
- Remembrance of things past: HLA genes come back on the allergy stage.
- A SOCS-1 promoter variant is associated with total serum IgE levels.
- Gene-environment interactions in human disease: nuisance or opportunity?
- Farm living: effects on childhood asthma and allergy.
- Environmental determinants of and impact on childhood asthma by the bacterial community in household dust.
- NF45 and NF90 regulate HS4-dependent interleukin-13 transcription in T cells.
- Phylogenetic and functional analysis identifies Ets-1 as a novel regulator of the Th2 cytokine gene locus.
- An allergy-associated polymorphism in a novel regulatory element enhances IL13 expression.
- Advances in asthma and allergy genetics in 2007.
- Advances in asthma, allergy mechanisms, and genetics in 2006.
- Functional dissection identifies a conserved noncoding sequence-1 core that mediates IL13 and IL4 transcriptional enhancement.
- Exposure to a farming environment has allergen-specific protective effects on TH2-dependent isotype switching in response to common inhalants.
- The human IL-13 locus in neonatal CD4+ T cells is refractory to the acquisition of a repressive chromatin architecture.
- Mechanisms of the hygiene hypothesis--molecular and otherwise.
- IL-21 effects on human IgE production in response to IL-4 or IL-13.
- TOLL-like receptor 10 genetic variation is associated with asthma in two independent samples.
- Polymorphisms in toll-like receptor 4 are not associated with asthma or atopy-related phenotypes. Previous years
- Discovering susceptibility genes for asthma and allergy.
- Gene-environment interactions: the road less traveled by in asthma genetics.
- Gene-environment interactions in asthma and allergy: the end of the beginning?
- Key advances in mechanisms of asthma, allergy, and immunology in 2009.
- The farm effect, or: when, what and how a farming environment protects from asthma and allergic disease.
- Th2 cell-selective enhancement of human IL13 transcription by IL13-1112C>T, a polymorphism associated with allergic inflammation.
- Of flaky tails and itchy skin.
- Genetics and biology of asthma 2010: La' ci darem la mano...
- The Faustian bargain of genetic association studies: bigger might not be better, or at least it might not be good enough.
- Single nucleotide polymorphisms in innate immunity genes: abundant variation and potential role in complex human disease.
- Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): frequencies, pairwise linkage disequilibrium, and haplotypes in three U.S. ethnic groups and exploratory case-control disease association studies.
- Genetics of IL-13 and functional relevance of IL-13 variants.
- Inhibition of CXCR4-tropic HIV-1 infection by lipopolysaccharide: evidence of different mechanisms in macrophages and T lymphocytes.
- Myb proteins repress human Ig epsilon germline transcription by inhibiting STAT6-dependent promoter activation.
- The functional genomics of CD14 and its role in IgE responses: an integrated view.
- c-Rel is a selective activator of a novel IL-4/CD40 responsive element in the human Ig gamma4 germline promoter.
- Novel insights into class switch recombination.
- Arginase: marker, effector, or candidate gene for asthma?
- S epsilon S mu and S epsilon S gamma switch circles in human nasal mucosa following ex vivo allergen challenge: evidence for direct as well as sequential class switch recombination.
- Association of defensin beta-1 gene polymorphisms with asthma.
- IL-13 R130Q, a common variant associated with allergy and asthma, enhances effector mechanisms essential for human allergic inflammation.
- Genetic regulation of IgE responses: Achilles and the tortoise.
- Rethinking Th2 antibody responses and allergic sensitization.
- Genetics, epigenetics, and the environment: switching, buffering, releasing.
- Innate immunity: sensing the environment and regulating the regulators.
- Genetic polymorphism in allergy and asthma.
- The regulation of IgE synthesis.